Significant positive correlations were found between global SLEDAI 2K scores and RQ of TRIM8 mRNA (r = 0.692, p = 0.001) and lnc-SSBP2-1:1 lncRNA expression (r = 0.600, p = 0.001), while hsa-miR-126-5p expression had a significant negative correlation (r =  − 0.517, p = 0.001) as shown in Table 3 and Fig. 2.In the active LN group, RQ of hsa-miR-126-5p expression levels showed a negative correlation to serum albumin (r =− 0.521, p = 0.001), and lnc-SSBP2-1:1 expression level had a negative correlation to the duration of the disease (r = − 0.353, p = 0.026). This evidence concerns the gene TRIM8 and lobular neoplasia.