Lnc-SSBP2-1:1 may function as a molecular sponge for hsa-miR-126-5p in this axis, decreasing its capacity to inhibit TRIM8. The resulting TRIM8 derepression may increase NF-κB and type I interferon signaling, which would increase the release of pro-inflammatory cytokines and endothelial dysfunction [36–38]. This evidence concerns the gene NFKB1 and endothelial dysfunction.