AGER and neurodegenerative disease: Conversely, among the significantly downregulated DEGs, we found enrichment of genes associated with neuronal functions, such as DBX1 and CSPG5; genes related to synaptic functions, such as ICSF21, KNDC1, and SERPINI1; genes involved in cell signaling, such as SLC1A3 and SLC16A9; genes implicated in transcriptional regulation, such as FOXN4 and HOPX; genes associated with neurodegenerative diseases, such as SLC27A3, AGER, and PLA2G6 (Fig. 3e).