Alternatively, the tumor microenvironment of triple negative breast cancer (which is similar to our ER/PR negative with low HER2 patients) is also characterized by heightened inflammation, potentially increasing the risk for toxicities, particularly with metastatic disease in the lung, but we did not find an association between lung metastases and pneumonitis [31–33]. The gene discussed is PGR; the disease is metastatic neoplasm.