EV biomarkers were correlated with multiple TC clinicopathological features, such as LNM, TNM stage, tumour size, extrathyroidal extension, pre- vs. postoperative levels, BRAF V600E mutation, radioiodine resistance, tumour recurrence, recurrence-free survival, overall survival, increasing tumour burden, vascular invasion, and distant metastasis. The gene discussed is BRAF; the disease is neoplasm.