ERAP2 and cancer: Examining gene expression of SCAA-loss APGs, we observed that ERAP2 (SCAA-loss in three cancers and three adenomas), had considerably lower expression in the affected cancers than in normal tissue (mean variance stabilizing transformation (VST) count = 6.8 versus 7.9) and in unaffected cancers (mean VST count = 8.1; Extended Data Fig. 3b,c).