CD274 and neoplasm: The fraction of cells belonging to CN3 (highly enriched for PD-L1+ cells, including PD-L1+ epithelial cells) was significantly higher in invasive margin and node deposits than in superficial tumor, while CN10 (also with general enrichment for PD-L1+ cells) was present at similar proportions in all tumor-associated regions (Extended Data Fig. 10c,d).