CDK7 controls the cell cycle at different levels by phosphorylating CDKs 1, 2, 4, and 6 in their T-loops promoting their activation.10–13 Additionally, the CAK complex is a key component of the transcription factor TFIIH involved in transcription initiation and elongation.14 Furthermore, CDK7 is aberrantly overexpressed in various cancer types15–17 and significant progress has been made in developing selective CDK7 inhibitors. The gene discussed is CDK7; the disease is cancer.