Intriguingly, our results show that only highly metastatic TNBC cells exhibit increased HERPUD1 expression and UPR activation in response to PA, suggesting the presence of subtype-specific features related to lipid metabolism in BC cell lines [61] Indeed, MDA-MB-231 cells, a well-established model of highly aggressive TNBC, have been described to efficiently incorporate PA, after its activation by ACSL3, into complex structural lipids within membranes [62]. This evidence concerns the gene HERPUD1 and breast cancer.