However, we have noticed upon interrogation of the Broad Institute depository (Depmap) that RNF4 silencing is more toxic to SS than it is  to 30 other cancer subtypes (Fig. 2J), confirming our hypothesis  that increased SMARCE1 expression is the linchpin of the exquisite toxicity of TAK-981 in SS. The gene discussed is RNF4; the disease is cancer.