Importantly, it has been recently demonstrated that in clear cell meningioma (CCM), a cancer driven by loss of SMARCE1, the cBAF complex fails to stabilize on chromatin, attenuating its activity36, underlying the role of SMARCE1 in sustaining the integrity of the cBAF complex, by driving cBAF complex stabilization on chromatin through cross-link interactions with other cBAF components, like ARID1A, but not PBAF subunits36. This evidence concerns the gene ARID1A and cerebral cavernous malformation.