KDM2B is a histone demethylase and component of a non-canonical polycomb repressive complex 1 (PRC1.1), that has been reported by Banito et al. to function as a mediator for the oncogenic activity of SS18::SSX1, contributing to synovial sarcomagenesis and the SS signature. This evidence concerns the gene KDM2B and synovial sarcoma.