Furthermore, overexpression of SMARCB1 is sufficient to restore cBAF genome-wide occupancy and to block the growth of SS cells14, while disruption of the ncBAF-only components BRD9 or GLTSCR1 abrogates ncBAF function, which also results in blocking the growth of SS cells10,12. The gene discussed is SMARCB1; the disease is synovial sarcoma.