PGF and placental abruption: This angiogenic imbalance has been demonstrated by several authors in patients with placental dysfunction-related disorders, including preeclampsia, FGR, preterm birth, and placental abruption.19, 20, 21, 22, 23 During pregnancy, the placenta secretes VEGF-A and PlGF, glycoproteins promoting the proliferation, migration, and activation of endothelial cells.24