PGF and coronary artery disorder: Gaining this understanding could improve early detection and lead to personalized interventions to reduce adverse outcomes in this high-risk population.PerspectivesCOMPETENCY IN MEDICAL KNOWLEDGE: This study demonstrates that pregnant women with CHD exhibit a placental angiogenic imbalance, with elevated sFlt-1 and reduced PlGF levels in late pregnancy, associated with higher rates of obstetric and neonatal complications.