Women with CHD had higher third-trimester sFlt-1 (2,578 pg/mL [25th-75th percentile: 2,095-4,493 pg/mL] vs 1,983 pg/mL [25th-75th percentile: 1,414-2.788 pg/mL], P = 0.002) and lower PlGF (276 pg/mL [25th-75th percentile: 164-510 pg/mL] vs 515 pg/mL [25th-75th percentile: 289-752 pg/mL], P = 0.005) than controls, resulting in an elevated sFlt-1/PlGF ratio (9.55 [25th-75th percentile: 3.88-26.70]) vs 3.83 [25th-75th percentile: 1.91-7.32], P = 0.001). The gene discussed is PGF; the disease is coronary artery disorder.