Numerous evidence has established that EA stimulation could effectively activate the cholinergic anti-inflammatory pathway, yielding notable anti-inflammatory benefits in a range of inflammatory conditions, including neuroinflammation,31 enteritis,26 and pancreatitis.32 Wang, et al.31 (2021) showed that EA treatment significantly upregulated α7-nAChR expression, thereby reducing the production of critical inflammatory mediators. The gene discussed is CHRNA7; the disease is pancreatitis.