Concerned that the extensive, mature tauopathy in the rTg4510 mouse may be resistant to inhibition of IL-1R signaling, or that the restricted distribution of parenchymal injections might account for failure of IL-1RA to reduce tauopathy, we next tested IL-1RA in a less aggressive model of tauopathy, PS19 [18], using a systemically administered rAAV capsid we previously found had widespread and relatively uniform transduction throughout the brain (Fig 6C) [23]. Here, IL1R1 is linked to tauopathy.