DROSHA and Macrocephaly: Also mutations in gene DICER1 (Dicer 1, Ribonuclease III), the ninth most important gene in the SHAP plot for Comm_50, have been shown to increase the risk of various cancers (DICER1 syndrome) [67,68] and to be related to delays in overall development (global developmental delay), macrocephaly, ASD and various physical abnormalities [69–73].