The tumor celldeath was associated with immunogenic cell death (ICD), as indicatedby the translocation of the damage-associated molecular patterns,in particular high mobility group box 1 (HMGB1) and calreticulin (CRT).Overall, these results highlight the potential of LMNVs as a remotelyactivatable nanoplatform capable of reprogramming microglia and topromote antitumor immunity in GBM. This evidence concerns the gene CALR and glioblastoma.