OPTN and amyotrophic lateral sclerosis: Mendelian Studies have identified multiple loci with a strong predisposition linked to ALS, including hexanucleotide expansions in chromosome 9 open reading frame 72 (C9orf72),and mutations in superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TARDBP), fused in sarcoma (FUS), Optineurin (OPTN) and TANK-binding kinase 1 (TBK1) (Renton et al., 2011; Rosen et al., 1993; Sreedharan et al., 2008; Vance et al., 2009; Maruyama et al., 2010; Freischmidt et al., 2015).