Isobutyl-deoxynyboquinone (IB-DNQ) is a potent and specific NQO1-bioactivatable futile redox cycling molecule that, combined with the inhibition of superoxide dismutase 1 (SOD1), can specifically increase the killing effect on tumor stem cells (CSCs) and induce mitochondrial oxidative damage, cyt c release, and activation of the caspase-3-mediated apoptotic pathway, effectively inhibiting the growth, metastasis and tumor-initiating potential of TNBC [48]. Here, CASP3 is linked to neoplasm.