ATP2B2 encodes the ATPase plasma membrane Ca2+ transporting 2 or plasma membrane Ca2+-ATPase type 2 (PMCA2) protein, a Ca2+ extrusion pump that helps maintain intracellular calcium levels in inner hair cells, and was originally linked to autosomal dominant non-syndromic hearing loss (DFNA82) in humans in 2019 [82], but identified as a deafness gene in the mouse nearly two decades prior [83]. This evidence concerns the gene DNAH8 and deafness.