For example, biallelic variants in AIRIM, encoding the AFG2 interacting ribosome maturation factor, have been shown to disrupt recycling of RSL24D1 (Ribosomal L24 Domain Containing 1) from cytoplasmic pre-60S ribosome subunits back to the nucleolus, resulting in a ribosomopathy characterized by microcephaly, developmental delay, and early-onset SNHL [13]. This evidence concerns the gene AIRIM and Global developmental delay.