The discrepancy of how La3+ had no effect on STICs recorded from ICC-LC but abolished Ca2+ waves in other ICC-LC was not resolved, and later experiments concluded that the primary Ca2+ influx pathway for sustaining spontaneous activity in rabbit urethral ICC-LC was reverse mode Na+-Ca2+ exchange (NCX) and not SOCE [85,87,88]. This evidence concerns the gene TLX2 and intrahepatic cholangiocarcinoma.