These findings corroborate previous work by Li et al, who showed that LDHA knockdown suppresses pancreatic ductal adenocarcinoma proliferation both in vitro and in vivo by inhibiting histone H3K18 lactylation.[42] Collectively, this compelling evidence establishes LDHA as a master regulator of cellular lactylation dynamics. This evidence concerns the gene LDHA and pancreatic ductal adenocarcinoma.