SIRT2 and familial pancreatic carcinoma: For example, sirtuin 2 (SIRT2) promoted the enzymatic activity of LDHA by decreasing its acetylation.[15] Palmitoylation altered LDHA activity and the response to chemotherapy of pancreatic cancer.[16] Succinylation attenuated the proteasomal degradation of LDHA by affecting its protein stability.[17] Thus, clarifying the regulatory mechanisms of PTM on LDHA in cancer is important for us to deeply understand the role of LDH in tumor progression.