For example, sirtuin 2 (SIRT2) promoted the enzymatic activity of LDHA by decreasing its acetylation.[15] Palmitoylation altered LDHA activity and the response to chemotherapy of pancreatic cancer.[16] Succinylation attenuated the proteasomal degradation of LDHA by affecting its protein stability.[17] Thus, clarifying the regulatory mechanisms of PTM on LDHA in cancer is important for us to deeply understand the role of LDH in tumor progression. This evidence concerns the gene SIRT2 and pancreatic neoplasm.