demonstrated that zinc finger DHHC‐type palmitoyltransferase 9 (ZDHHC9)‐mediated palmitoylation serves as a positive regulator of LDHA, enhancing its enzymatic activity through increased palmitoylation and consequently conferring chemoresistance in pancreatic adenocarcinoma.[16] These paradigm‐shifting findings collectively establish post‐translational modifications as critical determinants of LDHA activity. The gene discussed is LDHA; the disease is pancreatic adenocarcinoma.