RBM12 and vascular disorder: Finally, RBM12 is a poorly characterized RNA-binding protein likely implicated in the regulation of premRNA splicing.35 PTVs in RBM12 appeared to increase the risk of vascular disease across all 3 subphenotypes studied with ≈3-fold increase in odds of coronary, cerebrovascular, and peripheral vascular diseases (Figure 2; Table S5).