LDLR and familial hypercholesterolemia: Carriers of PTVs in LDLR exhibited an almost 5-fold increase in odds of ASCVD (OR, 4.87 [95% CI, 3.19–7.44]; P=1.30×10−13; carriers=75; case prevalence=37%) that was driven predominantly by disease in the peripheral and coronary circulation (Figure 2; Table S5), consistent with existing data on monogenic familial hypercholesterolemia.23–25