HTRA1 and ischemic stroke: It is well-established that heterozygous carriage of loss-of-function variants in HTRA1 increases risk of ischemic stroke and imaging biomarkers of cerebrovascular disease.29–31 However, this association was driven by both an increased risk of disease in both the coronary (OR, 1.38 [95% CI, 1.15–1.64]; P=5.4×10−4) and cerebrovasculature (OR, 1.78 [95% CI, 1.42–2.24]; P=5.50×10−7; Figure 2; Table S5).