HTRA1 and atherosclerosis: To assess the biological plausibility of this hypothesis, we examined the expression distribution of these genes in the Stockholm-Tartu Atherosclerosis Reverse Network Engineering Task database, which contains transcriptomic data from patients undergoing coronary artery bypass grafting and controls.38 Consistent with the known biology of HTRA1, it was robustly expressed in the aorta and mammary artery (aorta: median expression [Q1, Q3]=385 [308, 475] cpm; internal mammary artery: median expression [Q1, Q3]=241 [206, 280] cpm).