A previous study has reported PTVs in RBM12 to segregate with psychosis in an Icelandic and Finnish cohort but did not comment on ASCVD disease in this pedigree.52 The molecular function of SGTB is poorly characterized, but its homologue SGTA has a well-described role as a molecular chaperone.33 Our work provides impetus to elucidate the role of these proteins in vascular cells and to study their impact on atherosclerosis in model systems to provide orthogonal validation of these hypothesis-generating findings. This evidence concerns the gene SGTA and atherosclerosis.