Missense variants (Rare Exome Variant Ensemble Learner score >0.5) in SGTB appeared to raise risk of ASCVD primarily via effects in the coronary and peripheral circulation (Figure 2; OR (coronary), 2.51 [95% CI, 1.63–3.85]; P=1.5×10−5; OR (peripheral), 2.92 [95% CI, 1.34–6.34]; P=4.8×10−3). The gene discussed is SGTB; the disease is atherosclerosis.