LIN28A and neoplasm: Outside of aptamers, an RNA ligand based off of the RNA consensus binding element of an RBP was functionalized with a NASA electrophile capable of transferring a hydrophobic tag to its cognate binding proteins, Lin28a, leading to degradation of this protein.138 As Lin28a inhibits productions of let-7 miRNA, there was a subsequent increase in these mature miRNAs, which act as tumor suppressors.161