These CD8+ CD45RA− CD69+ CXCR5+ PD1+ FoxP3+ IKZF3+ cells, which we annotated as follicular regulatory CD8+ T cells (CD8+ Tfr), were significantly enriched in DLBCL and FL compared to rLNs (Figure 4h). The gene discussed is IKZF3; the disease is diffuse large B-cell lymphoma.