IFNA1 and Aicardi-Goutieres syndrome: The accumulating nucleic acids aberrantly activate the cGAS–STING pathway, leading to pathological IFN production (interferonopathy) [62], a 6‐month, open‐label phase II trial demonstrated that treatment with the RTase inhibitor lamivudine significantly CNS inflammatory markers (including cerebrospinal fluid IFN scores) in 60% of pediatric AGS patients, with concurrent improvements in motor function.