POMC and Anxiety: On the other hand, non-food-related stressors, such as physical restraint, social defeat, subordination, or social isolation, have a crucial role in the release of adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH), which induce anxiety-like behaviors connected with maladaptive eating behaviors (Razzoli et al., 2015; Molina-Hidalgo et al., 2023; Ding et al., 2021; Cortés-García et al., 2022).