For example, both NR4A1 and ANXA5 were associated with ulcerative colitis (UC) (8, 25); NR4A1 expressed in intestine tissues, inflammatory cells and epithelium (26, 27), regulated the differentiation and function of Paneth cell (28); ANXA5 had differential expression in the jejunal mucosa of IUGR and normal piglets (10). This evidence concerns the gene ANXA5 and fetal growth restriction.