However, tumor tissues often exhibit an altered iron metabolism characterized by increased iron uptake and retention, a phenomenon known as “iron addiction.” Many malignancies, such as breast cancer, prostate cancer, and hepatocellular carcinoma, achieve this by upregulating TFR1 to enhance iron uptake while downregulating FPN to reduce iron export, ensuring a continuous supply of iron to support rapid tumor proliferation and metabolic reprogramming (1, 13). Here, TFRC is linked to neoplasm.