AKT1 and ischemic stroke: In ischemic stroke, cerebral ischemia/reperfusion rapidly triggers iron accumulation, lipid peroxidation, and GPX4/SLC7A11 depression; the ferroptosis inhibitor ferrostatin-1 reduces infarct volume and improves neurobehavioral outcomes in middle cerebral artery occlusion (MCAO) models, consistent with an Protein kinase B/Glycogen Synthase Kinase 3 Beta (AKT/GSK3β)-dependent protection (53).