A heatmap further revealed that tumor-suppressive proteins (FOXO3A, DIRAS3, cleaved PARP, SMAD4, CD20, and P53) were positively correlated with NRG1, while oncogenic proteins (YB1, PKCβII, HER2, β-catenin, GSK3, and AKT) were negatively correlated with NRG1. Here, SMAD4 is linked to neoplasm.