Likewise, analyses of the subventricular zone (SVZ) in MS show a 2–3 fold increase in cell density and proliferation, with PSA-NCAM+ early glial progenitors being up to 8-fold more numerous in active and chronic-active lesions compared with chronic silent lesions, shadow plaques, or normal-appearing white matter (10). Here, NCAM1 is linked to myeloid sarcoma.