Guan et al. (Guan et al., 2014) found through research that SGD and PF could significantly reduce the production of prostaglandin E2 (PGE2) and prostaglandin F2α (PGF2α), and significantly inhibit the mRNA expression levels of estrogen receptor α (ER - α) and oxytocin receptor (OTR), revealing the potential mechanism of action of SGD in the treatment of adenomyosis and providing a scientific basis for the ethno - pharmacological application of this traditional formula. This evidence concerns the gene ESR1 and adenomyosis.