Because GSK3β is a crucial autophagy regulator, inhibiting it increases autophagic activity, essential for removing toxic protein aggregates associated with neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease (Sun et al., 2016; Weikel et al., 2016). This evidence concerns the gene GSK3B and early-onset autosomal dominant Alzheimer disease.