Malnutrition activates the nuclear factor kappa-B (NF-κB) pathway, promoting the release of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), which induce myocardial fibrosis and microvascular dysfunction. Here, NFKB1 is linked to Myocardial fibrosis.