Rare variants in other genes, such as LIPA (lysosomal acid lipase), LIPG (endothelial lipase), LIPC (hepatic lipase), and PNPLA5 (patatin-like phospholipase domain-containing protein 5), can also result in FH-like phenotypes, usually in isolated pedigrees only (4). The gene discussed is LIPC; the disease is familial hyperaldosteronism.