HIF1A and neoplasm: We propose the following mechanistic explanations for these findings: (1) HIF-1α promotes glucose uptake by tumor cells, enhancing their proliferation and metabolic ability, leading to enhanced cellular density that restricts water molecule diffusion (30); (2) HIF-1α is known to stimulate tumor angiogenesis by regulating downstream factors such as VEGF, consequently increasing tissue perfusion (31).