The research aims to explore the predictive significance of diffusion-weighted imaging (DWI), diffusion kurtosis imaging (DKI), intravoxel incoherent motion (IVIM), and their integrated models in relation to Hypoxia-inducible factor-1 alpha (HIF-1α), Ki-67, and vascular endothelial growth factor (VEGF) expression levels in breast carcinoma. This evidence concerns the gene HIF1A and breast carcinoma.