AKT1 and diffuse large B-cell lymphoma: Hypoxia is a hallmark of aggressive DLBCL, which helps lymphoma cells adapt to long-term hypoxia microenvironment by upregulating proteins involved in glucose utilization, degrading mitochondrial proteins for potential mitochondrial recycling, and becoming more reliant on BCL-2 and PI3K-AKT-mTOR signaling for survival (10).