In DLBCL, siRNA-mediated knockdown of ANXA1 significantly downregulates pro-apoptotic proteins such as Bcl-2-associated X protein (Bax) and cleaved caspase-3, while upregulating anti-apoptotic protein Bcl-2 and pro-inflammatory cytokines (e.g., TNF-α, IL-6), indicating that ANXA1 has dual functions in promoting apoptosis and suppressing inflammation (32). The gene discussed is BCL2; the disease is diffuse large B-cell lymphoma.