Hypoxic stress profoundly remodels molecular landscapes in Non-Hodgkin B-cell malignancies, triggering adaptive modifications in key mediators of tumor survival such as glucose transporter 1 (GLUT-1/SLC2A1), carbonic anhydrase isoforms (CAIX/CA9 and CAXII/CA12), and vascular endothelial growth factor (VEGF) (11). Here, CA12 is linked to neoplasm.