In contrast, tumor suppressor pathways such as TP53 and CDKN2A/p16 were represented by fewer miRNAs, and SMAD4-TGFβ signaling, despite its established relevance in pancreatic cancer, was not reflected in our figure due to the limited reporting of related miRNAs in circulating biomarker studies. The gene discussed is SMAD4; the disease is pancreatic neoplasm.