SMAD4 and familial pancreatic carcinoma: In contrast, tumor suppressor pathways such as TP53 and CDKN2A/p16 were represented by fewer miRNAs, and SMAD4-TGFβ signaling, despite its established relevance in pancreatic cancer, was not reflected in our figure due to the limited reporting of related miRNAs in circulating biomarker studies.