Regarding p16 expression in relation to clinicopathological parameters of the studied cases, there were statistically significant associations between p16 expression and tumor site (P = 0.005), risk stratification (P < 0.001), mitotic index (P < 0.001), local recurrence (P = 0.001), distant metastasis (P = 0.001), lymph nodes involvement (P = 0.024), and CD117 expression (P = 0.015). This evidence concerns the gene KIT and neoplasm.