Therefore, these variations highlight the need for further multi-centric studies with standardized methodologies, integrating molecular subtyping such as KIT, PDGFRA mutations, Succinate dehydrogenase (SDH) deficiency, and cell cycle regulatory pathways, to better define the prognostic significance of these markers. This evidence concerns the gene PDGFRA and hyperinsulinemic hypoglycemia, familial, 4.