Key prognostic variables, such as the thickness of the tumour, the largest basal diameter, histopathological features, and cytogenetic alterations (e.g., monosomy 3, BAP1 status), are not available in SEER and could not be incorporated. Furthermore, site coding within SEER may not always clearly distinguish iris from ciliary body melanoma, raising potential for misclassification [30]. The gene discussed is BAP1; the disease is neoplasm.