ATP8B1 and alpha 1-antitrypsin deficiency: In children, inherited causes are more commonly associated with liver disease leading to cirrhosis. Causative conditions include Wilson's disease, alpha-1-antitrypsin deficiency, primary sclerosing cholangitis, biliary atresia in infants, Alagille syndrome, mitochondrial hepatopathies, hepatitis, MDR3 deficiency, FIC1 deficiency, and glycogen storage disorders [9,10].