MMP2 and diabetic foot: The study demonstrated that the levels of MMP-2 were two- to six-fold higher and MMP-9 were 14-fold significantly higher in diabetic foot ulcers. The study also provided evidence for the reduced expression of TIMP-2 in diabetics than in non-diabetics. Among the proteases that have been reported to be increased in chronic wounds are the MMPs, specifically MMP-9, highlighting its utility as a biomarker [4,5].