CD40LG and autoimmune polyendocrinopathy: At 12 weeks, autoimmune testing confirmed persistently elevated anti-β2-glycoprotein-I IgM and anti-cardiolipin IgM, with negative lupus anticoagulant, fulfilling the revised Sydney APS classification criteria (Table 2) [4]. At four years of follow-up, the patient has remained free of APS-related complications under long-term warfarin therapy.