Complete loss of Kcnt1 produced deficits in open-field behavior, motor skill learning, and anxiety-like behavior, but no defect in spatial learning.  Kcnt1 -/- mice were protected from death after maximum electroshock-induced seizures. Heterozygous Kcnt1 +/R455H mice had increased seizure susceptibility and activity, supporting the hypothesis that increased K Na current leads to epilepsy. The gene discussed is KCNT1; the disease is epilepsy.