KCNT1 and epilepsy: Building upon this foundation, subsequent investigations identified that Slack channels are implicated in ID; notably, mutations in the KCNT1 gene, which encodes Slack, have been found in early-onset epileptic encephalopathies, where they are associated with severe cognitive delays. The SLACK channel has been implicated in ID-related epilepsies, including malignant migrating partial seizures of infancy, autosomal dominant nocturnal frontal lobe epilepsy, and Ohtahara syndrome [9,13,14].