A pan-cancer analysis demonstrates that higher expression of PIK3R1 is significantly associated with a better overall survival rate in many solid tumors, including lung adenocarcinoma, stomach adenocarcinoma, kidney renal clear cell carcinoma, and liver hepatocellular carcinoma, suggesting a tumor-suppressive role for PIK3R1 [323] (Figure 9D). This evidence concerns the gene PIK3R1 and neoplasm.