This study suggests that presynaptic α-Syn accumulation may trigger cell-to-cell transmission of aggregates, leading to apoptotic death of acceptor neurons in Lewy body diseases. Defective autophagy induced by upregulated mTOR and downregulated ATG7 may lead to neurodegeneration due to the accumulation of α-Syn in postmortem tissues of DLB cases and α-Syn transgenic mice [195]. Here, MTOR is linked to Lewy body dementia.