ANKIB1 and Alzheimer disease: Using the GEO2R tool, the analysis of microarray gene expression data of the GSE48350 dataset revealed that the expression of two genes [FRAS1-related extracellular matrix 3 (166752, FREM3) and ankyrin repeat and IBR domain-containing 1 (54467, ANKIB1)] was upregulated in the HC of male AD patients (n = 9, age range: 76-94 years) compared to male controls (n = 10, age range: 75-97 years) (Data Appendix B, Data S24).