Postmortem cortical gray matter tissues of secondary progressive MS (SPMS) individuals exhibit that cell death of cortical neurons occurs through necroptosis dependent on the TNF/TNFR1 signaling pathway involving the activation of Fas-associated via death domain (FADD), RIPK1, RIPK3, and mixed lineage kinase domain-like pseudokinase (MLKL) [227]. The gene discussed is FADD; the disease is myeloid sarcoma.