DYRK1A-driven tau pathology contributes to neurodegeneration not only in AD (Ryoo et al., 2007; Shukla et al., 2023; Zhu et al., 2022) but also in other tauopathies, including Pick’s disease (PiD) (Ferrer et al., 2005), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) (Shi et al., 2008), and frontotemporal dementia (FTD) (Deboever et al., 2022; Yin et al., 2017). Here, DYRK1A is linked to frontotemporal dementia.