DYRK1A and Alzheimer disease: Considering the vital protective role of astrocytes, their contribution to neuronal death when pathologically impaired (Huang et al., 2025), and their sensitivity to the pathological events of AD (Arranz and De Strooper, 2019), expanding the study of DYRK1A’s pathophysiology to include astrocytes holds the potential to reveal novel mechanisms contributing to the neurodegenerative process in AD.