In neurons differentiated from DS patient-derived iPSCs, normalizing DYRK1A levels restored the expression of several presynaptic proteins—including Synaptotagmin 1/3, Contactin-associated protein, Secretory Carrier Membrane 5, Endophilins (SH3GL2 & SH3GL3), Synaptic Vesicle Glycoprotein, and Intersectin 1—thereby improving vesicle dynamics and NT release (Wu et al., 2022). This evidence concerns the gene DYRK1A and Dravet syndrome.