In DS mice, DYRK1A overdosage reduced neuronal firing rates and gamma oscillations in the prefrontal cortex, associated with lower vesicular γ-aminobutyric acid (GABA) transporter (VGAT) expression and impaired GABA loading into inhibitory synaptic vesicles (Ruiz-Mejias et al., 2016; Saito et al., 2010; Shih et al., 2023; Figure 3D, bottom). Here, DYRK1A is linked to Dravet syndrome.