SOX2 and skin squamous cell carcinoma: In addition, semiautomatic digital scoring of oral squamous cell carcinoma (SCC), which shares common histological features with cSCC, categorized SOX2 protein expression as 'absent/low' or 'high' on the basis of H-score cut-off values (absent/low SOX2 expression: H-scores of 0–11; high SOX2 expression: H-score ≥ 11) (Steen et al, 2025).