In our cohort, we did not detect significant over or underexpression (FDR-adjusted P < .5) or substantial differential expression (log2 fold change < 2.0) of TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, SMAD5, and others in EB-cSCC compared with those in UV-induced cSCC. Here, SMAD5 is linked to skin squamous cell carcinoma.