The activated STING can promote the phosphorylation and activation of PERK, and induce the expression of type I interferon (IFN-I) and pro-inflammatory factors through the TBK1 signaling pathway, further exacerbating inflammation and cell damage.(Zhang et al., 2022; Zhang et al., 2024) Therefore, if antioxidant natural compounds can mitigate the cisplatin - induced ERS, they can alleviate AKI more rapidly and effectively. The gene discussed is STING1; the disease is acute kidney injury.