In this study, we observed that AHRE can enhance β-cell regeneration, increase insulin secretion, and alleviate hyperglycemia in T1DM rats, accompanied by the upregulation of the protein expression of p-EGFR and cyclin E, which are significant transcription factors in regeneration, development, and maturation of pancreatic β-cells. This evidence concerns the gene CCNE1 and type 1 diabetes mellitus.