Nilotinib, a potent tyrosine kinase inhibitor member, and polyphenol recover the pancreatic β-cell function through the increase of antioxidant defense system and decrease of oxidative stress as well as the increase of PI3K/Akt/PDX-1 signaling in STZ-induced type 1 diabetic rat models (53, 54). Here, AKT1 is linked to type 1 diabetes mellitus.