Western diet (e.g. high-fat diet, HFD) is one of the critical factors of HCE development, as it alters lipogenesis-linked enzyme expression (e.g. liver X receptor α/β, LXRa/β; acetyl-CoA carboxylase, ACC; and fatty acid synthase, FAS), consequently causing dyslipidemia (3). The gene discussed is NR1H3; the disease is metabolic syndrome.