AIFM2 and malignant colon neoplasm: At the same time, studies have shown that there is a close connection exists between NAT10 and ferroptosis during tumor progression; for example, NAT10 plays a critical role in colon cancer development by affecting ferroptosis-suppressor-protein 1 (FSP1) mRNA stability and ferroptosis, suggesting that NAT10 could be a novel prognostic and therapeutic target in colon cancer (Zheng et al., 2022).