On the other hand, NAT10 also upregulates ANKZF1 protein expression by mediating the ac4C modification of ANKZF1 mRNA; ANKZF1 inhibits the cytoplasmic retention of YAP1 by competitively binding with YWHAE, promoting YAP1 nuclear translocation and its transcriptional activity, and ultimately activates pro-lymphangiogenic factors, driving lymphangiogenesis and tumor progression in ccRCC. Here, NAT10 is linked to nonpapillary renal cell carcinoma.