On the one hand, NAT10 (activated by HIF-1α transcription) enhances the stability of NFE2L3 mRNA through catalyzing ac4C modification, thereby upregulating LASP1 expression, activating the AKT/GSK3β/β-catenin signaling pathway, and promoting tumor cell proliferation, migration, in vivo growth, and metastasis in ccRCC (Sun et al., 2025). This evidence concerns the gene AKT1 and nonpapillary renal cell carcinoma.