Notably, genetically predicted elevated levels of lymphotoxin-α (LTA; OR = 1.132, 95% confidence interval [CI]: 1.052–1.217, P = .001), interleukin-18 receptor 1 (OR = 1.233, 95% CI: 1.049–1.448, P = .011), interleukin-10 receptor subunit β (OR = 1.098, 95% CI: 1.012–1.192, P = .024), and thymic stromal lymphopoietin (OR = 1.241, 95% CI: 1.012–1.522, P = .038) were significantly associated with increased OM susceptibility. Here, IL18R1 is linked to ocular melanoma.