TNFRSF11B and ocular melanoma: OPG, a decoy receptor for receptor activator of nuclear factor kappa-Β ligand, inhibits osteoclast-mediated bone resorption, thereby preserving bone architecture in OM.[39–41] In addition to skeletal protection, OPG has been shown to modulate inflammatory cytokine production, suggesting a dual role in immune regulation and bone homeostasis.