Ginkgolides, distinguished terpenoid compounds within ginkgo leaves, have captured significant scientific interest, particularly Ginkgolide B and K. Ginkgolide K, in MPTP PD models, orchestrates a reduction in GFAP and Iba-1 expression, curtails the microglial activation and the astrocytic activation, thereby diminishes NO, TNF-α, and IL-1β levels while enhancing TGF-β and IL-10 concentrations. The gene discussed is AIF1; the disease is Parkinson disease.