Tanshinone is a diterpenoid derived from Salvia miltiorrhiza, and the main active ingredients are tanshinone I and tanshinone IIA.[161] Tanshinone I showcases its neuroprotective prowess in MPTP-induced PD mouse models by reducing Iba-1 expression and inhibiting microglial activation. This evidence concerns the gene AIF1 and Parkinson disease.