Apigenin, within LPS-induced PD rats, reduces striatal concentrations of TNF-α, IL-1β, IL-6, iNOS, and NO by downregulating the TLR4/NF-κB pathway with precision and simultaneously amplifying the Nrf2/HO-1 pathway’s voice, thus dialing down neuroinflammation.[194]. Here, TNF is linked to Parkinson disease.