TNF and Parkinson disease: Hesperidin, a bioflavonoid with a high concentration in citrus fruits,[140] can reduce the release of TNF-α, IFN-γ, IL-1β, IL-2, and IL-6 in the striatum of PD mouse models induced by 6-OHDA, inhibiting neuroinflammation, protecting dopaminergic neurons, and alleviating depressive, anxious, and dyskinetic behaviors in PD mice.[141]