SNCA and Parkinson disease: Central to the PD narrative is α-synuclein, a neuroprotein ubiquitously expressed in various brain regions (SN, midbrain, etc) and peripheral sites like the intestines, playing a pivotal role in PD-related inflammation.[10] Structurally, α-synuclein comprises 3 domains: an N-terminal α-helical region that interfaces with lipid vesicles and cell membranes, a hydrophobic NAC domain, and a C-terminal replete with negative charges and hydrophilicity.[11] Ordinarily, α-synuclein remains highly soluble and aggregation-resistant.