NLRP3 and Parkinson disease: Salidroside, derived from the Rhodiola genus roots, emerges as a promising agent against PD.[185] In MPTP-induced PD mice, salidroside exhibits mechanism involves downregulating the TLR4/NF-κB and NLRP3/Caspase-1 pathways, leading to reduced activity of NLRP3 and Caspase-1.