NOS2 and Parkinson disease: Furthermore, in LPS-induced PD mouse BV2 cells, tanshinone I lowers TNF-α, IL-6, IL-1β, and iNOS levels, effectively countering neuroinflammation.[162] In 6-OHDA-induced PD rat, tanshinone IIA mitigates NF-κB activity, reduces IL-1β, TNF-α, and INF-γ levels, and increases IL-10 levels, thereby alleviating neuroinflammation and easing abnormal rotation and muscle rigidity.[163] Tanshinone IIA also diminishes CD11b expression in the SNpc, curtails microglial activation, and decreases iNOS levels in MPTP-induced PD mice, further reducing neuroinflammation.[164]