This series of actions helps safeguard dopaminergic neurons.[178] Moreover, in MPTP PD zebrafish, glycyrrhizin’s interaction with HMGB1 and modulation of the TLR/NFκB pathway downregulates the release of IL-1β and IL-6, prevention of abnormal α-synuclein aggregation, inhibition of neuroinflammation, protection of dopaminergic neurons, and amelioration of motor impairments.[179]. This evidence concerns the gene SNCA and Parkinson disease.