TNF and Parkinson disease: Moreover, its ability to downregulate Iba-1, stifle microglial activation, and dampen the NLRP3 inflammasome’s zeal by suppressing NF-κB, effectively diminishes TNF-α, IL-1β, and IL-6 levels, offering solace from neuroinflammation.[190] Baicalin prowess extends to LPS-induced PD mice, where it elevates Nrf2 and HO-1, curbing IL-1β and TNF-α secretion and further easing neuroinflammation.[191]